The results identified a specific signature of a group of genes in the regions of the brain which are most vulnerable to Alzheimer’s disease. Healthy individuals with this specific gene signature are highly likely to develop Alzheimer’s disease in later life, and would most benefit from preventative treatments, if and when they are developed for human use.
Alzheimer’s disease, the most common form of dementia, is characterised by the progressive degeneration of the brain. Not only is the disease currently incurable, but its molecular origins are still unknown. Human bodies have a number of defence mechanisms which protect it against protein aggregation, but as people age, these defences get weaker, which is why Alzheimer’s generally occurs in later life.
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